Article

Link to google scholar

36. A minimalist design approach to simple coacervates from low molecular weight components

Ryou Kubota*

Polymer J. accepted. DOI: 10.1038/s41428-025-01037-5

perspective article

33. Supramolecular-polymer composite hydrogels: from in situ network observation to functional properties

Ryou Kubota*

Bull. Chem. Soc. Jpn 96, 820– 812 (2023). DOI: 10.1246/bcsj.20230129

Review article, open access

29. Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue

Kento Ojima, Wataru Kakegawa, Masayuki Ito, Yuta Miura, Yukiko Michibata, Ryou Kubota, Tomohiro Doura, Tokiwa Yamasaki, Eriko Miura, Hiroshi Nonaka, Seiya Mizuno, Satoru Takahashi, Michisuke Yuzaki, Itaru Hamachi, Shigeki Kiyonaka

Nature Commun. 13, 3167 (2022). DOI: 10.1038/s41467-022-30828-0

28. Shape-selective one-step synthesis of branched gold nanoparticles on the crystal surface of redox-active PdII macrocycles

Yutaro Yamashita, Shohei Tashiro, Yoshiki Ishii, Takayuki Uchihashi, Nobuyuki Matsushita, Ryou Kubota, Mitsuhiko Shionoya

Dalton Trans. 51,1318–1324 (2022). DOI: 10.1039/d1dt03973c

27. Photo-triggered Spatially Controlled Out-of-Equilibrium Patterns of Peptide Nanofibers in a Self-sorting Double Network Hydrogel

Keisuke Nakamura, Wataru Tanaka, Kei Sada, Ryou Kubota, Takuma Aoyama, Kenji Urayama, Itaru Hamachi

J. Am. Chem. Soc. 143, 19532–19541 (2021). DOI: 10.1021/jacs.1c09172

26. Microscopic Imaging Techniques for Molecular Assemblies: Electron, Atomic Force, and Confocal Microscopies

Ryou Kubota, Wataru Tanaka, Itaru Hamachi

Chem. Rev. 121, 14281–14347 (2021). DOI: 10.1021/acs.chemrev.0c01334

25. Face-selective adsorption of a prochiral compound on the chiral pore-surface of metal-macrocycle framework (MMF) directed towards stereoselective reactions

Shohei Tashiro, Tsutomu Umeki, Ryou Kubota, Mitsuhiko Shionoya

Faraday Discuss. 225, 197–209 (2021). DOI: 10.1039/D0FD00019A

24. In situ real-time confocal imaging of a self-assembling peptide-grafted polymer showing pH-responsive hydrogelation

Ryou Kubota, Shogo Torigoe, Shuang Liu, Itaru Hamachi

Chem. Lett. 49, 1319–1323 (2020). DOI: 10.1246/cl.200513

23. Control of seed formation allows two distinct self-sorting patterns of supramolecular nanofibers

Ryou Kubota, Kazutoshi Nagao, Wataru Tanaka, Ryotaro Matsumura, Takuma Aoyama, Kenji Urayama, Itaru Hamachi

Nature Commun. 11, 4100 (2020). DOI: 10.1038/s41467-020-17984-x

22. Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems

Hajime Shigemitsu*, Ryou Kubota*, Keisuke Nakamura, Tomonobu Matsuzaki, Saori Minami, Kenji Urayama, Itaru Hamachi (*: contributed equally)

Nature Commun. 11, 3859 (2020). DOI: 10.1038/s41467-020-17698-0 (open access)

highlighted by Kyoto University

21. Force generation by a propagating wave of supramolecular nanofibers

Ryou Kubota, Masahiro Makuta, Ryo Suzuki, Masatoshi Ichikawa, Motomu Tanaka, Itaru Hamachi

Nature Commun. 11, 3541 (2020). DOI: 10.1038/s41467-020-17394-z (open access)

 highlighted by Kyoto University

20. Core-shell metal-macrocycle framework (MMF): spatially selective dye inclusion through core-to-shell anisotropic transport along crystalline 1D-channels connected by epitaxial growth 

Shohei Tashiro, Shinya Mitsui, David W. Burke, Ryou Kubota, Nobuyuki Matsushita, Mitsuhiko Shionoya

CrystEngComm 22, 1306–1309 (2020). DOI: 10.1039/D0CE00120A

20. Core-shell metal-macrocycle framework (MMF): spatially selective dye inclusion through core-to-shell anisotropic transport along crystalline 1D-channels connected by epitaxial growth 

Shohei Tashiro, Shinya Mitsui, David W. Burke, Ryou Kubota, Nobuyuki Matsushita, Mitsuhiko Shionoya

CrystEngComm 22, 1306–1309 (2020). DOI: 10.1039/D0CE00120A

19. The power of confocal scanning laser microscopy in supramolecular chemistry: in situ real-time imaging of stimuli-responsive multicomponent supramolecular hydrogels

Ryou Kubota, Keisuke Nakamura, Shogo Torigoe, Itaru Hamachi

ChemistryOpen 9, 67–79 (2020). DOI: 10.1002/open.201900328

18. pH Nanosensor Using Electronic Spins in Diamond

Takahiro Fujisaku, Ryotaro Tanabe, Shinobu Onoda, Ryou Kubota, Takuya F. Segawa, Frederick T.-K. So, Takeshi Ohshima, Itaru Hamachi, Masahiro Shirakawa, Ryuji Igarashi

ACS Nano 13, 11726–11732 (2019). DOI: 10.1021/acsnano.9b05342

17. Post-assembly fabrication of a functional multicomponent supramolecular hydrogel based on a self-sorting double network

Wataru Tanaka, Hajime Shigemitsu, Takahiro Fujisaku, Ryou Kubota, Saori Minami, Kenji Urayama, Itaru Hamachi

J. Am. Chem. Soc. 141, 4997–5004 (2019). DOI: 10.1021/jacs.9b00715

16. On-cell coordination chemistry: chemogenetic activation of membrane-bound glutamate receptors in living cells

Ryou Kubota, Shigeki Kiyonaka, Itaru Hamachi

Methods in Enzymology 622, 411–430 (2019). DOI: 10.1016/bs.mie.2019.02.0233

15. Molecular Technologies in Life Innovation: Novel molecular technologies for labeling and functional control of proteins under live cell conditions

Itaru Hamachi, Shigeki Kiyonaka, Tomonori Tamura, Ryou Kubota

Molecular Technology 2, 294–328 (2018)

14. Rational synthesis of benzimidazole[3]arenes by CuII catalyzed post-macrocyclization transformation

Shohei Tashiro, Tsutomu Umeki, Ryou Kubota, Mitsuhiko Shionoya

Chemical Science 9, 7614–7619 (2018).  DOI: 10.1039/C8SC03086C (Open access)

13. Chemogenetic approach using Ni(II) complex–agonist conjugates allows selective activation of class A G-protein-coupled receptors

Ryou Kubota, Wataru Nomura, Takuma Iwakasa, Kento Ojima, Shigeki Kiyonaka, Itaru Hamachi

ACS Central Science  4, 1211–1221 (2018). DOI: 10.1021/acscentsci.8b00390 (Open Access)

12. Imaging-based study on control factors over self-sorting of supramolecular nanofibers formed from peptide- and lipid-type hydrogelators

Ryou Kubota, Shuang Liu, Hajime Shigemitsu, Keisuke Nakamura, Wataru Tanaka, Masato Ikeda, Itaru Hamachi

Bioconjugate Chem. 29, 2058–2067 (2018). DOI: acs.bioconjchem.8b00260 (Open Access)

selected as ACS editors' choice

11. An adaptive supramolecular hydrogel comprising self-sorting double nanofibre networks

Hajime Shigemitsu, Takashiro Fujisaku, Wataru Tanaka, Ryou Kubota, Saori Minami, Kenji Urayama, Itaru Hamachi

Nature Nanotechnol. 13, 165–172 (2018). DOI: 10.1038/s41565-017-0026-6

highlighted in Press release from Kyoto University

10. Non-covalent immobilisation of p-toluenesulfonic acid in a porous molecular crystal for size-specific acid-catalysed reactions

Shohei Tashiro, Hirotaka Yonezawa, Ryou Kubota, Tsutomu Umeki, Mitsuhiko Shionoya

Chem. Commun. 52, 7657–7660 (2016). DOI: 10.1039/C6CC02621D

9. Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells

Shigeki, Kiyonaka*, Ryou Kubota*, Yukiko Michibata, Masayoshi Sakakura, Hideo Takahashi, Tomohiro Numata, Ryuji Inoue, Michisuke Yuzaki, Itaru Hamachi

Nature Chem. 8, 958-967 (2016) DOI: 10.1038/nchem.2554 (*: contributed equally).

highlighted in Press release from Kyoto University, EurekAlert!, Chem-station

8. In situ real-time imaging of self-sorted supramolecular nanofibres

Shoji Onogi, Hajime Shigemitsu, Tatsuyuki Yoshii, Tatsuya Tanida, Masato Ikeda, Ryou Kubota, Itaru Hamachi

Nature Chem. 8, 743–752 (2016). DOI: 10.1038/nchem.2526

highlighted in News and views, Press release from Kyoto University, EurekAlert!

selected as a front cover

7. Chiral Metal-Macrocycle Frameworks: supramolecular chirality induction and helicity inversion of the helical metal-macrocyclic structures

Ryou Kubota, Shohei Tashiro, Mitsuhiko Shionoya

Chem. Sci. 7, 2217–2221 (2016). DOI: 10.1039/C5SC04570C

6. Protein recognition using synthetic small-molecular binders toward optical sensing in vitro and in live cells

Ryou Kubota, Itaru Hamachi

Chem. Soc. Rev. 44, 4454–4471 (2015). DOI: 10.1039/C4CS00381K

5. In situ X-ray snapshot analysis of transient molecular adsorption in a crystalline channel

Ryou Kubota, Shohei Tashiro, Motoo Shiro, Mitsuhiko Shionoya

Nature Chem. 6, 913–918 (2014). DOI: 10.1038/nchem.2044

highlighted in 東京大学理学部プレスリリース, Chem-Station 

4. Simultaneous arrangement of up to three different molecules on the pore surface of metal-macrocycle framework (MMF): cooperation and competition

Shohei Tashiro, Tsutomu Umeki, Ryou Kubota, Mitsuhiko Shionoya

Angew. Chem. Int. Ed. 53, 8310–8315 (2014). DOI: 10.1002/anie.201404179

Selected as a Frontispiece

3. Palladium- or proton-induced submicro spherical aggregation of macrocyclic amphiphiles in aqueous soluiton

Shohei Tashiro, Ryou Kubota, Minori Kawagoe, Mitsuhiko Shionoya

Dalton. Trans. 42, 15915–15918 (2013). DOI: 10.1039/C3DT51827B

2. Non-covalent surface modification of metal-macrocycle framework with mono-substituted benzenes

Ryou Kubota, Shohei Tashiro, Tsutomu Umeki, Mitsuhiko Shionoya

Supramol. Chem. 24, 867–877 (2012). DOI: 10.1080/10610278.2012.733394

1. Metal-macrocycle framework (MMF): supramolecular nano-channel surfaces with shape sorting capability

Shohei Tashiro, Ryou Kubota, Mitsuhiko Shionoya

J. Am. Chem. Soc. 134, 2461–2464 (2012). DOI: 10.1021/ja209422m